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2499-2502
Potent and Selective Carboxylic Acid-Based Inhibitors of Matrix Metalloproteinases
Stanislaw Pikul,
Norman E. Ohler,
Greg Ciszewski,
Michael C. Laufersweiler,
Neil G. Almstead,
Biswanath De,
Michael G. Natchus,
Lily C. Hsieh,
Michael J. Janusz,
Sean X. Peng,
Todd M. Branch,
Selane L. King,
Yetunde O. Taiwo, and
Glen E. Mieling
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2503-2506
Experimental Precedent for the Need To Involve the Primary Hydration Layer of DNA in Lead Drug Design
Sophia Y. Breusegem,
Seyed E. Sadat-Ebrahimi,
Kenneth T. Douglas,
Elena V. Bichenkova,
Robert M. Clegg, and
Frank G. Loontiens
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2507-2510
A Rational Approach to the Design of Selective Substrates and Potent Nontransportable Inhibitors of the Excitatory Amino Acid Transporter EAAC1 (EAAT3). New Glutamate and Aspartate Analogues as Potential Neuroprotective Agents
Giuseppe Campiani,
Meri De Angelis,
Silvia Armaroli,
Caterina Fattorusso,
Bruno Catalanotti,
Anna Ramunno,
Vito Nacci,
Ettore Novellino,
Christof Grewer,
Diana Ionescu,
Thomas Rauen,
Roger Griffiths,
Colin Sinclair,
Elena Fumagalli, and
Tiziana Mennini
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2511-2522
Novel Selective PDE4 Inhibitors. 1. Synthesis, Structure-Activity Relationships, and Molecular Modeling of 4-(3,4-Dimethoxyphenyl)-2H-phthalazin-1-ones and Analogues
Margaretha Van der Mey,
Armin Hatzelmann,
Ivonne J. Van der Laan,
Geert J. Sterk,
Ulrich Thibaut, and
Hendrik Timmerman
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2523-2535
Novel Selective PDE4 Inhibitors. 2. Synthesis and Structure-Activity Relationships of 4-Aryl-Substituted cis-Tetra- and cis-Hexahydrophthalazinones
Margaretha Van der Mey,
Armin Hatzelmann,
Gerard P. M. Van Klink,
Ivonne J. Van der Laan,
Geert J. Sterk,
Ulrich Thibaut,
Wolf R. Ulrich, and
Hendrik Timmerman
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2536-2543
Design, Synthesis, DNA Binding, and Biological Evaluation of Water-Soluble Hybrid Molecules Containing Two Pyrazole Analogues of the Alkylating Cyclopropylpyrroloindole (CPI) Subunit of the Antitumor Agent CC-1065 and Polypyrrole Minor Groove Binders
Pier Giovanni Baraldi,
Gianfrano Balboni,
Maria Giovanna Pavani,
Giampiero Spalluto,
Mojgan Aghazadeh Tabrizi,
Erik De Clercq,
Jan Balzarini,
Toshikazu Bando,
Hiroshi Sugiyama, and
Romeo Romagnoli
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2544-2554
Structure-Based Design, Synthesis, and Biological Evaluation of Conformationally Restricted Novel 2-Alkylthio-6-[1-(2,6-difluorophenyl)alkyl]- 3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase
Antonello Mai,
Gianluca Sbardella,
Marino Artico,
Rino Ragno,
Silvio Massa,
Ettore Novellino,
Giovanni Greco,
Antonio Lavecchia,
Chiara Musiu,
Massimiliano La Colla,
Chiara Murgioni,
Paolo La Colla, and
Roberta Loddo
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2555-2564
Structural Studies on Bioactive Compounds. 34. Design, Synthesis, and Biological Evaluation of Triazenyl-Substituted Pyrimethamine Inhibitors of Pneumocystis carinii Dihydrofolate Reductase
David C. M. Chan,
Charles A. Laughton,
Sherry F. Queener, and
Malcolm F. G. Stevens
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2565-2574
Disabling ErbB Receptors with Rationally Designed Exocyclic Mimetics of Antibodies: Structure-Function Analysis
Alan Berezov,
Hong-Tao Zhang,
Mark I. Greene, and
Ramachandran Murali
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2575-2585
Original 2-Alkylamino-6-halogenoquinazolin-4(3H)-ones and KATP Channel Activity
Fabian Somers,
Raogo Ouedraogo,
Marie-Hélène Antoine,
Pascal de Tullio,
Bénédicte Becker,
Jeanine Fontaine,
Jacques Damas,
Léon Dupont,
Benoit Rigo,
Jacques Delarge,
Philippe Lebrun, and
Bernard Pirotte
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2586-2592
Design and Synthesis of Potent and Selective  4 7 Integrin Antagonists
Jürgen Boer,
Dirk Gottschling,
Anja Schuster,
Monika Semmrich,
Bernhard Holzmann, and
Horst Kessler
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2593-2600
Structure-Activity Studies of Ground- and Transition-State Analogue Inhibitors of Cyclophilin
Harry C. Wang,
Kyonghee Kim,
Ray Bakhtiar, and
Juris P. Germanas
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2601-2611
The Effect of 1,3-Diaryl-[1H]-pyrazole-4-acetamides on Glucose Utilization in ob/ob Mice
Gregory R. Bebernitz,
Greg Argentieri,
Beverly Battle,
Christine Brennan,
Bork Balkan,
Bryan F. Burkey,
Michele Eckhardt,
Jiaping Gao,
Prasad Kapa,
Robert J. Strohschein,
Herbert F. Schuster,
Mary Wilson, and
David D. Xu
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2612-2618
Synthesis of Cytotoxic 6E-Hydroximino-4-ene Steroids: Structure/Activity Studies
Noé Deive,
Jaime Rodríguez, and
Carlos Jiménez
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2619-2635
Synthesis of 6- and 7- Hydroxy-8-azabicyclo[3.2.1]octanes and Their Binding Affinity for the Dopamine and Serotonin Transporters
Peter C. Meltzer,
Bing Wang,
Zhengming Chen,
Paul Blundell,
Muthusamy Jayaraman,
Mario D. Gonzalez,
Clifford George, and
Bertha K. Madras
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2636-2660
Design, Synthesis, and Structure-Activity Relationships of Macrocyclic Hydroxamic Acids That Inhibit Tumor Necrosis Factor Release in Vitro and in Vivo
Chu-Biao Xue,
Matthew E. Voss,
David J. Nelson,
James J.-W. Duan,
Robert J. Cherney,
Irina C. Jacobson,
Xiaohua He,
John Roderick,
Lihua Chen,
Ronald L. Corbett,
Li Wang,
Dayton T. Meyer,
Kenneth Kennedy,
William F. DeGrado ,
Karl D. Hardman,
Christopher A. Teleha,
Bruce D. Jaffee,
Rui-Qin Liu,
Robert A. Copeland,
Maryanne B. Covington,
David D. Christ,
James M. Trzaskos,
Robert C. Newton,
Ronald L. Magolda,
Ruth R. Wexler, and
Carl P. Decicco
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2661-2666
Thiazolidine Prodrugs as Protective Agents against  -Radiation-Induced Toxicity and Mutagenesis in V79 Cells
Britta H. Wilmore,
Pamela B. Cassidy,
Raymond L. Warters, and
Jeanette C. Roberts
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2667-2670
Reduced Amide Bond Peptidomimetics. (4S)-N-(4-Amino-5-[aminoalkyl]aminopentyl)-N'-nitroguanidines, Potent and Highly Selective Inhibitors of Neuronal Nitric Oxide Synthase
Jung-Mi Hah,
Linda J. Roman,
Pavel Martásek, and
Richard B. Silverman
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2671-2674
Synthesis and Evaluation of Oxodioxolenylmethyl Carbamate Prodrugs of Pseudomycins
Xicheng Sun,
Michael Rodriguez,
Doug Zeckner,
Bobbie Sachs,
William Current,
Robert Boyer,
Jonathan Paschal,
Carl McMillian, and
Shu-Hui Chen
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2675-2678
(-)3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic Acid [(-)DRF 2725]: A Dual PPAR Agonist with Potent Antihyperglycemic and Lipid Modulating Activity
Braj B. Lohray,
Vidya B. Lohray,
Ashok C. Bajji,
Shivaramayya Kalchar,
Rajamohan R. Poondra,
Srinivas Padakanti,
Ranjan Chakrabarti,
Reeba K. Vikramadithyan,
Parimal Misra,
Suresh Juluri,
N. V. S. Rao Mamidi, and
Ramanujam Rajagopalan
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